Fertility & Reproductive

Kisspeptin-10 (Kp-10) is a bioactive 10-amino acid peptide derived from the KISS1 gene, corresponding to amino acids 45-54 of metastin. It acts as a critical regulator of reproductive function through activation of the GPR54 receptor, stimulating the release of gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Originally discovered for its anti-metastatic properties in cancer, kisspeptin-10 has emerged as a key player in the hypothalamic-pituitary-gonadal axis. The peptide shows therapeutic potential for fertility disorders including PCOS, hypothalamic amenorrhea, and male hypogonadism. It is currently experimental with no FDA approval and is classified as a substantial safety risk for compounding pharmacy use.