MGF

MGF (Mechano Growth Factor) is a splice variant of Insulin-like Growth Factor 1 (IGF-1) that plays a crucial role in muscle repair, tissue regeneration, and neuroprotection. It is produced in response to mechanical stress and muscle damage, activating satellite cells and promoting tissue healing. MGF is also known as IGF-1Ec in humans and IGF-1Eb in rodents, characterized by a unique E domain resulting from alternative splicing of the IGF-1 gene.

Benefits

• Accelerates muscle repair and recovery after exercise-induced damage
• Activates and proliferates satellite cells (muscle stem cells)
• Promotes muscle hypertrophy and prevents age-related muscle loss (sarcopenia)
• Enhances osteoblast proliferation and accelerates bone fracture healing
• Provides neuroprotection against ischemic brain injury and neurotoxicity
• Promotes neurogenesis in the aging brain, particularly in the hippocampus
• Reduces cardiac dysfunction and improves cardiac function after myocardial infarction
• Modulates inflammatory response and enhances anti-inflammatory macrophage activity
• Stimulates angiogenesis and vascular regeneration
• Reduces apoptosis in muscle cells and cardiomyocytes
• May help treat muscular dystrophy and other muscle wasting conditions
• Promotes wound healing and tissue regeneration across multiple tissue types